The red pill and its counterpart, the blue pill, are popular culture symbols representing the choice between embracing the sometimes painful truth of reality (red pill) and the blissful ignorance of illusion (blue pill).
The concept was popularized by the 1999 film ‘The Matrix,’ in which the protagonist is offered the choice of remaining in the fabricated reality of a computer simulation, living the ‘ignorance of illusion,’ or the freedom to live the ‘truth of reality’ even though it is a harsher, more difficult life.
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The Daily Omnivore 