Melatonin [mel-uh-toh-nin] is a naturally occurring hormone found in animals, plants, and microbes. In animals, circulating levels of melatonin vary in a daily cycle, thereby allowing the entrainment of the circadian rhythms of several biological functions.
Many biological effects of melatonin are produced through activation of melatonin receptors, while others are due to its role as a pervasive and powerful antioxidant (a molecule that neutralizes free radicals), with a particular role in the protection of nuclear and mitochondrial DNA. Products containing melatonin have been available over-the-counter in the United States since the mid-1990s. In many other countries, the sale of this neurohormone is not permitted or requires a prescription.
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Melatonin
Dark Therapy
Dark therapy is an experimental treatment which involves eliminating all light in the subject’s environment, for a period of six to sixteen hours per day, in combination with a regular sleep schedule. Dark therapy manipulates circadian rhythms acting on hormones and neurotransmitters. It has been proposed recently (2005) to combine the chronobiological manipulations of light/dark and/or sleep/wake therapies with psychopharmacological medication.
In the words of Swiss neuroscientist Anna Wirz-Justice: ‘Light therapy has undergone widespread controlled randomized clinical trials, and wake therapy has been so widely studied over decades that the efficacy data are strong. These nonpharmaceutical, biologically based therapies are not only powerful adjuvants, but also antidepressants in their own right… [P]ilot studies suggest that the simple measure of promoting long nights (more rest, more sleep, no light) can stop rapid cycling in bipolar patients, or diminish manic symptoms — intriguing findings that require replication.
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Segmented Sleep
Segmented sleep, also known as divided sleep, bimodal sleep pattern, or interrupted sleep, is a polyphasic or biphasic sleep pattern where two or more periods of sleep are punctuated by a period of wakefulness. Along with a nap (siesta) in the day, it has been argued that this is the natural pattern of human sleep. A case has been made that maintaining such a sleep pattern may be important in regulating stress.
Historian A. Roger Ekirch argues that before the Industrial Revolution, segmented sleep was the dominant form of human slumber in Western civilization. He draws evidence from documents from the ancient, medieval, and modern world, which he discovered over the course of fifteen years of research. Other historians, such as Craig Koslofsky, have endorsed Ekirch’s discovery and analysis.
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Transsexualism
Transsexualism describes the condition in which an individual identifies with a gender inconsistent or not culturally associated with their assigned sex, i.e. in which a person’s assigned sex at birth conflicts with their psychological gender. A medical diagnosis can be made if a person experiences discomfort as a result of a desire to be a member of the opposite sex, or if a person experiences impaired functioning or distress as a result of that gender identification.
Transsexualism is stigmatized in many parts of the world but has become more widely known in Western culture in the mid to late 20th century, concurrently with the sexual revolution and the development of sex reassignment surgery (SRS). Discrimination or negative attitudes towards transsexualism often accompany certain religious beliefs or cultural values. However, some cultures have less difficulty integrating people who change gender roles, often holding them with high regard, such as the traditional role for ‘two-spirit’ people found among certain native American tribes.
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God Gene
The God gene hypothesis proposes that a specific gene (VMAT2) predisposes humans towards spiritual or mystic experiences. The idea has been postulated by geneticist Dean Hamer, the director of the Gene Structure and Regulation Unit at the U.S. National Cancer Institute, and author of the 2005 book ‘The God Gene: How Faith is Hardwired into our Genes.’ The God gene hypothesis is based on a combination of behavioral genetic, neurobiological, and psychological studies.
The major arguments of the theory are: (1) spirituality can be quantified by psychometric measurements; (2) the underlying tendency to spirituality is partially heritable; (3) part of this heritability can be attributed to the gene VMAT2; (4) this gene acts by altering monoamine levels; and (5) spiritual individuals are favored by natural selection because they are provided with an innate sense of optimism, the latter producing positive effects at either a physical and psychological level.
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Help at Any Cost
‘Help at Any Cost: How the Troubled-Teen Industry Cons Parents and Hurts Kids’ is a 2006 non-fiction book by science journalist Maia Szalavitz analyzing the controversy surrounding the tough love behavior modification industry. Szalavitz focuses on four programs: Straight, Incorporated, a copy of the Straight Inc. program called KIDS, North Star wilderness boot camp, and the World Wide Association of Specialty Programs and Schools.
She discusses the background, history and methodology of the troubled teen industry, including techniques drawn from attack therapy, Erhard Seminars Training (est), and Synanon, all of which are highly controversial. She uses first-person accounts and court testimony in her research, and states that no evidence exists proving that these programs are effective. The book also includes advice for parents and an appendix with additional resources on how to get responsible help for teenagers.
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Magical Thinking
Magical thinking is thinking that one’s thoughts by themselves can bring about effects in the world or that thinking something corresponds with doing it. It is a type of causal reasoning or causal fallacy that looks for meaningful relationships of grouped phenomena between acts and events. In religion, folk religion, and superstition, the correlation posited is between religious ritual, such as prayer, sacrifice, or the observance of a taboo, and an expected benefit or recompense.
In clinical psychology, magical thinking is a condition that causes the patient to experience irrational fear of performing certain acts or having certain thoughts because they assume a correlation with their acts and threatening calamities. ‘Quasi-magical thinking’ describes ‘cases in which people act as if they erroneously believe that their action influences the outcome, even though they do not really hold that belief.’
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Human Vestigiality
In the context of human evolution, human vestigiality [ve-stij-ee-al-i-tee] involves those characters (such as organs or behaviors) occurring in the human species that are considered vestigial—in other words having lost all or most of their original function through evolution. Although structures usually called ‘vestigial’ often appear functionless, a vestigial structure may retain lesser functions or develop minor new ones.
In some cases, structures once identified as vestigial simply had an unrecognized function. The examples of human vestigiality are numerous, including the anatomical (such as the human appendix, tailbone, wisdom teeth, and inside corner of the eye), the behavioral (goose bumps and infant grasp reflex), sensory (decreased olfaction), and molecular (junk DNA). Many human characteristics are also vestigial in other primates and related animals.
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Life Extension
Life extension science, also known as anti-aging medicine and experimental gerontology, is the study of slowing down or reversing the processes of aging to extend both the maximum and average lifespan.
Some researchers in this area, and ‘life extensionists’ or ‘longevists’ (those who wish to achieve longer lives themselves), believe that future breakthroughs in tissue rejuvenation with stem cells, molecular repair, and organ replacement (such as with artificial organs or xenotransplantations) will eventually enable humans to have indefinite lifespans (agerasia) through complete rejuvenation to a healthy youthful condition.
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Free-radical Theory of Aging
The free radical theory of aging states that organisms age because cells accumulate free radical damage over time. A free radical is a molecule with an unpaired electron. The molecule is reactive and seeks another electron to pair. This initiates an uncontrolled chain reaction that can damage the natural function of the living cell, causing various diseases. While a few free radicals such as melanin are not chemically reactive, most biologically-relevant free radicals are highly reactive.
For most biological structures, free radical damage is closely associated with oxidative damage. Antioxidants are reducing agents, they limit oxidative damage to biological structures by donating an electron to free radicals. Biogerontologist Denham Harman first proposed the free radical theory of aging in the 1950s, and in the 1970s extended the idea to implicate mitochondrial production of reactive oxygen species.
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SENS
Strategies for Engineered Negligible Senescence (SENS) is the term coined by British biogerontologist Aubrey de Grey for the diverse range of regenerative medical therapies, either planned or currently in development, for the periodical repair of all age-related damage to human tissue with the ultimate purpose of maintaining a state of negligible senescence in the patient, thereby postponing age-associated disease for as long as the therapies are reapplied.
The term ‘negligible senescence’ was first used in the early 1990s by professor Caleb Finch to describe organisms such as lobsters and hydras, which do not show symptoms of aging. The term ‘engineered negligible senescence’ first appeared in print in Aubrey de Grey’s 1999 book ‘The Mitochondrial Free Radical Theory of Aging,’ and was later prefaced with the term ‘strategies’ in the article ‘Time to Talk SENS: Critiquing the Immutability of Human Aging.’
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Negligible Senescence
Negligible [neg-li-juh-buhl] senescence [si-nes-sens] refers to the lack of symptoms of aging in a few select animals. More specifically, negligibly senescent animals do not have measurable reductions in their reproductive capability with age, or measurable functional decline with age.
Death rates in negligibly senescent animals do not increase with age as they do in senescent organisms. Some fish, such as some varieties of sturgeon and rockfish, and some tortoises and turtles are thought to be negligibly senescent.
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