Posts tagged ‘Intoxicant’

December 6, 2012



Cannabinoids [kuh-nab-uh-noid] are a class of diverse chemical compounds that activate cannabinoid receptors (molecules on the surface of a cells in the brain and throughout the body, which receive chemical signals). After the receptor is engaged, multiple intracellular signal pathways are activated; researchers are still unraveling the precise mechanism at work.

Cannabinoid receptors are activated by endocannabinoids (produced naturally in the body), phytocannabinoids (found in plants), and synthetic cannabinoids (produced chemically in a lab). The most notable cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC), the primary psychoactive compound of cannabis. However, there are known to exist dozens of other cannabinoids with varied effects. Before the 1980s, it was often speculated that cannabinoids produced their physiological and behavioral effects via nonspecific interaction with cell membranes, instead of interacting with specific membrane-bound receptors.

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November 15, 2012



native american church

An entheogen [en-theo-gen] (‘generating the divine within’) is a psychoactive substance used in a religious, shamanic, or spiritual context. Historically, entheogens were mostly derived from plant sources and have been used in a variety of traditional religious contexts.

Entheogens can supplement many diverse practices for healing, transcendence, and revelation, including: meditation, psychonautics, art projects, and psychedelic therapy. Entheogens have been used in a ritualized context for thousands of years. Examples of traditional entheogens include: peyote, psilocybin mushrooms, uncured tobacco, cannabis, ayahuasca, salvia, iboga, morning glory, and Amanita muscaria mushrooms.

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October 23, 2012


Albert Hofmann

Hallucinogens [huh-loo-suh-nuh-juhns] are drugs which can cause hallucinations (seeing, hearing, or otherwise perceiving things that are not real). They are a general group of pharmacological agents that can be divided into three broad categories: psychedelics (drugs with perception-altering effects), dissociatives (drugs that produce feelings of detachment – dissociation – from the environment and self), and deliriants (drugs that induce a state of delirium in the user).

These classes of psychoactive drugs have in common that they can cause subjective changes in perception, thought, emotion and consciousness. Unlike other psychoactive drugs, such as stimulants and opioids, these drugs do not merely amplify familiar states of mind, but rather induce experiences that are qualitatively different from those of ordinary consciousness. These experiences are often compared to non-ordinary forms of consciousness such as trance, meditation, dreams, or insanity.

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October 22, 2012



Melange [mey-lahnj] from French ‘mélange’ (‘set of diverse elements’) – also called the ‘spice’ – is the name of the fictional drug central to the ‘Dune’ series of science fiction novels by Frank Herbert, and derivative works.

In the series, the most essential and valuable commodity in the universe is melange, a geriatric drug that gives the user a longer life span, greater vitality, and heightened awareness; it can also unlock prescience (foreknowledge of events) in some humans, depending upon the dosage and the consumer’s physiology. This prescience-enhancing property makes safe and accurate interstellar travel possible. Melange comes with a steep price, however: it is addictive, and withdrawal is fatal.

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October 3, 2012

Alcohol Inhalation


Alcohol Without Liquid is a process introduced first in Asia and Europe that allows people to take in liquor (distilled spirits) without actually consuming liquid. The machine vaporizes alcohol and mixes it with oxygen, allowing the consumer to breathe in the mixture.

The machine has been dubbed AWOL, a play on the military term AWOL (Absent Without Leave). The AWOL machine produces a very fine alcoholic mist. The continual intake of this mist over a twenty-minute period is the equivalent of taking one shot of distilled spirits. The machine was introduced to the United States in 2004.

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September 11, 2012


Terence McKenna

Psilocybin [sil-uh-sahy-bin] is a naturally occurring psychedelic compound produced by more than 200 species of mushrooms, collectively known as psilocybin mushrooms. The most potent are members of the genus Psilocybe, such as P. azurescens, P. semilanceata, and P. cyanescens, but psilocybin has also been isolated from about a dozen other genera.

Psilocybin is quickly converted by the body to psilocin, which has mind-altering effects similar to those of LSD and mescaline. The effects generally include euphoria, visual and mental hallucinations, changes in perception, a distorted sense of time, and spiritual experiences, and can include possible adverse reactions such as nausea and panic attacks. Possession of psilocybin-containing mushrooms has been outlawed in most countries, and it has been classified as a scheduled drug by many national drug laws.

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May 18, 2012


mothers little helper by sarah golden

An anxiolytic [ang-zee-uh-lit-ik] is a drug used for the treatment of anxiety and its related psychological and physical symptoms. Anxiolytics have been shown to be useful in the treatment of anxiety disorders. Beta-blockers, although not anxiolytics, can be used to combat the somatic symptoms of anxiety (such as an elevated heart rate).

Anxiolytics are also known as minor tranquilizers. The term is less common in modern texts, and was originally derived from a dichotomy with major tranquilizers, also known as neuroleptics or antipsychotics.

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May 14, 2012


shulgin by ros plazma

Dimethoxybromoamphetamine (DOB), also known as Brolamfetamine and Bromo-DMA, is a psychedelic drug and substituted amphetamine of the phenethylamine (a neurotransmitter abundant in chocolate) class of compounds (e.g. MDMA). DOB was first synthesized by American pharmacologist Alexander Shulgin in 1967. In his book ‘PiHKAL: A Chemical Love Story,’ Shulgin lists the dosage range as 1 to 3 mg, which is generally taken orally. According to Shulgin, the effects of DOB last 18 to 30 hours. Onset of the drug is also long, sometimes taking up to three hours. The toxicity of DOB is not fully known, although high doses may cause serious vasoconstriction of the extremities.

DOB has been sold on blotter paper (and presumably represented as LSD). Misrepresentation as LSD could be potentially dangerous, as DOB does not have the known safety profile of LSD: unlike LSD, DOB can have physically harmful (if not fatal) effects in overdose. Upon tasting the chemical, if one notices a highly bitter or ‘chemically’ taste, this should serve as a warning sign that the drug is not LSD, but likely a psychedelic amphetamine (DOB, DOC, DOI, or Bromo-DragonFLY). However, blotter paper may have a taste regardless of the chemical on it, due to ink or solvent used.

April 29, 2012


rorer 714

Methaqualone is a sedative-hypnotic drug that is similar in effect to barbiturates, a general central nervous system depressant. The sedative-hypnotic activity was first noted by Indian researchers in the 1950s and in 1962 methaqualone itself was patented in the US by Wallace and Tiernan. Its use peaked in the early 1970s as a hypnotic, for the treatment of insomnia, and as a sedative and muscle relaxant.

It has also been used illegally as a recreational drug, commonly known as Quaaludes [kwey-lood], Sopors, Ludes, or Mandrax (particularly in the 1970s in North America) depending on the manufacturer. At that time ‘luding out’ was a popular college pastime. This is the similar effect of an alcoholic blackout with no recollection of events. Since at least 2001, it has been widely used in South Africa, where it is commonly referred to as ‘smarties’ or ‘geluk-tablette’ (meaning ‘happy tablets’). Clandestinely produced methaqualone is still seized by government agencies and police forces around the world.

April 19, 2012




Cannabidiol [kah-nuh-bi-dye-awl] (CBD) is a cannabinoid found in Cannabis. It is a major constituent of the plant, representing up to 40% in its extracts. It has displayed sedative effects in animal tests. Some research, however, indicates that CBD can increase alertness. It may decrease the rate of THC clearance from the body, perhaps by interfering with the metabolism of THC in the liver. Medically, it has been shown to relieve convulsion, inflammation, anxiety, and nausea, as well as inhibit cancer cell growth. Recent studies have shown cannabidiol to be as effective as atypical antipsychotics in treating schizophrenia.

A Cannabis Indica plant may have a CBD/THC ratio 4:-5 times that of Cannabis sativa. Marijuana with relatively high ratios of CBD:THC is less likely to induce anxiety than vice versa. This might partial be due to CBD’s antagonist effects at the cannabidanoid receptor, compared to THC’s partial agonist effect. The relatively large amount of CBD contained in Cannabis indica, means, compared to a sativa, the effects are modulated significantly. The effects of Sativa are well known for its cerebral high, hence used daytime as medical cannabis, while Indica are well known for its sedative effects and preferred night time as medical cannabis.

April 17, 2012



The terms empathogen [em-path-uh-jen] and entactogen are used to describe a class of psychoactive drugs that produce distinctive emotional and social effects similar to those of MDMA (‘Ecstasy’) characterized by increased empathy (the ability to understand and share the feelings of another). Putative members of this class include 2C-B, 2C-I, MDMA, MDA, MDEA, MBDB, 2C-T-7, and 2C-T-2, among others.

The chemical structure of many entactogens contains a substituted amphetamine core, and most belong to the phenethylamine class of psychoactive drugs, although several (AET and AMT) are tryptamines. When referring to MDMA and its counterparts, the term ‘MDxx’ is often used with the exception of MDPV.

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April 6, 2012



Bromo-DragonFLY is a psychedelic hallucinogenic drug related to phenethylamine (a chemical found in chocolate, which like amphetamine, causes the release of norepinephrine and dopamine in the brain). It is considered an extremely potent hallucinogen, only slightly less potent than LSD, with a normal dose in the region of 200 μg to 800 μg, and it has an extremely long duration (up to several days).

It is explicitly illegal only in Finland, Sweden, Norway, and Denmark, although it may be considered a controlled substance analogue under US and Australian drug laws. The compound was first synthesized in the lab of American pharmacologist David E. Nichols in 1998. As with the earlier and less potent dihydrofuran series of compounds nicknamed FLY, Bromo-DragonFLY was named after its superficial structural resemblance to a dragonfly.

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